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Matematicheskaya Biologiya i Bioinformatika, 2016, Volume 11, Issue Suppl., Pages t1–t14
DOI: https://doi.org/10.17537/2016.11.t1
(Mi mbb317)
 

This article is cited in 1 scientific paper (total in 1 paper)

Translations of Published Articles

REP-elements of the Escherichia coli genome and transcription signals: positional and functional analysis

N. Yu. Markelovaab, I. S. Masulisab, O. N. Ozolineab

a Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia
b Pushchino State Institute of Natural Sciences, Pushchino, Russia
Full-text PDF (861 kB) Citations (1)
References:
Abstract: In the intergenic regions of the Escherichia coli genome there are 356 REP-elements, containing 1–12 repeated sequences with degenerated consensus. Their biological role is poorly understood, but multiplicity in the genome, preferential localization between convergent genes and ability to form hairpin structures have led to the assumption that REP-elements participate in the transcription termination and processes affecting stability of the corresponding RNAs. Though the direct experiments did not confirm the ability of the studied REP-sequence to stop RNA synthesis and some ambiguity regarding their primary function still exists. In this study, positional and functional analysis was undertaken for the entire set of annotated REP-sequences and the reduced efficiency of RNA synthesis behind the many REP-modules was observed. For all that some REP-modules did not affect the processivity of RNA synthesis, assuming their read-through transcription and further possibility to be involved in the regulatory events. We also observed REP-associated transcription activation and found overlapping promoters. The most unexpected was specific distribution of REP-sequences nearby the promoter islands, which assumes an insulator-like action of these sequences, maintaining transcriptional autonomy of the islands, and indicates functional significance of the island-born RNAs.
Key words: structural elements of bacterial genome, REP-sequences, promoters, promoter islands, mechanisms of transcription regulation.
Funding agency Grant number
Russian Science Foundation 14-14-00985
The study was supported by the grant of the Russian Scientific Foundation (project №14-14-00985).
Received 22.03.2016, Published 28.03.2016
Document Type: Article
UDC: 579:252
Language: English
Citation: N. Yu. Markelova, I. S. Masulis, O. N. Ozoline, “REP-elements of the Escherichia coli genome and transcription signals: positional and functional analysis”, Mat. Biolog. Bioinform., 11, Suppl. (2016), t1–t14
Citation in format AMSBIB
\Bibitem{MarMasOzo16}
\by N.~Yu.~Markelova, I.~S.~Masulis, O.~N.~Ozoline
\paper REP-elements of the \emph{Escherichia coli} genome and transcription signals: positional and functional analysis
\jour Mat. Biolog. Bioinform.
\yr 2016
\vol 11
\pages t1--t14
\issueinfo Suppl.
\mathnet{http://mi.mathnet.ru/mbb317}
\crossref{https://doi.org/10.17537/2016.11.t1}
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    This publication is cited in the following 1 articles:
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