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Matematicheskaya Biologiya i Bioinformatika, 2016, Volume 11, Issue 2, Pages 263–277
DOI: https://doi.org/10.17537/2016.11.263 (Mi mbb274) 		 
Mathematical Modeling

Stoichiometric modeling of oxygen transportation through the surface of isolated perfused rat liver

K. V. Shadrinab, V. G. Pakhomovaa, A. P. Rupenkoa, O. V. Kryukovaa, R. G. Khleboproscda

a Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science
b Krasnoyarsk State Medical University
c Siberian Federal University
d Russian Academy of Science Siberian Branch Institute of Biophysics
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DOI: https://doi.org/10.17537/2016.11.263
Abstract: Stoichiometric modeling allows analyzing the features of metabolism both the cell populations and the holistic isolated organs. In this paper, one of the stoichiometric modeling methods, Flux Balance Analysis, was used to investigate the mechanisms of oxygen transportation through the surface of the isolated perfused rat liver at various oxygenation conditions. It is shown that the oxygen intake through the surface of the isolated perfused liver is associated with energy consumption.
Key words: stoichiometric modeling, the oxygen transportation, perfusion, hypoxia.
Received 13.09.2016, Published 14.11.2016
Document Type: Article
UDC: 577
Language: Russian
Citation: K. V. Shadrin, V. G. Pakhomova, A. P. Rupenko, O. V. Kryukova, R. G. Khlebopros, “Stoichiometric modeling of oxygen transportation through the surface of isolated perfused rat liver”, Mat. Biolog. Bioinform., 11:2 (2016), 263–277
Citation in format AMSBIB
\Bibitem{ShaPakRup16}
\by K.~V.~Shadrin, V.~G.~Pakhomova, A.~P.~Rupenko, O.~V.~Kryukova, R.~G.~Khlebopros
\paper Stoichiometric modeling of oxygen transportation through the surface of isolated perfused rat liver
\jour Mat. Biolog. Bioinform.
\yr 2016
\vol 11
\issue 2
\pages 263--277
\mathnet{http://mi.mathnet.ru/mbb274}
\crossref{https://doi.org/10.17537/2016.11.263}
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