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Matematicheskaya Biologiya i Bioinformatika, 2015, Volume 10, Issue 1, Pages 234–244
DOI: https://doi.org/10.17537/2015.10.234
(Mi mbb223)
 

This article is cited in 4 scientific papers (total in 4 papers)

Mathematical Modeling

Simulation of spontaneous activity in neuronal cultures with long-term plasticity

A. A. Degterev, M. S. Burtsev

National Research Centre "Kurchatov Institute", Moscow
Full-text PDF (953 kB) Citations (4)
References:
Abstract: Existence of spontaneous population bursts is a widely studied phenomenon observed in neuronal cultures in vitro. Recent models of neuronal cultures network activity consist of a number of burst generating mechanisms such as synaptic noise and presence of pacemaker neurons in the network. In the previous simulations of bursting in neuronal cultures synaptic weights change in accordance with the rule of short-term plasticity whereas the long-term values of them, and hence the network structure, remain unchanged. In this paper we reproduce neuronal network models with static synapses, and then investigate spontaneous activity changes in neuronal networks with long-term plasticity defined by STDP rule. Our results demonstrate that introduction of long-term plasticity in the model leads to discrepancy with the experimental data.
Key words: neuronal culture, synaptic plasticity, spike.
Funding agency Grant number
Russian Foundation for Basic Research 13-04-01273_а
Received 15.05.2015, Published 22.06.2015
Document Type: Article
UDC: 51–76
Language: Russian
Citation: A. A. Degterev, M. S. Burtsev, “Simulation of spontaneous activity in neuronal cultures with long-term plasticity”, Mat. Biolog. Bioinform., 10:1 (2015), 234–244
Citation in format AMSBIB
\Bibitem{DegBur15}
\by A.~A.~Degterev, M.~S.~Burtsev
\paper Simulation of spontaneous activity in neuronal cultures with long-term plasticity
\jour Mat. Biolog. Bioinform.
\yr 2015
\vol 10
\issue 1
\pages 234--244
\mathnet{http://mi.mathnet.ru/mbb223}
\crossref{https://doi.org/10.17537/2015.10.234}
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  • This publication is cited in the following 4 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
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    Full-text PDF :114
    References:66
     
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