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Matematicheskaya Biologiya i Bioinformatika, 2014, Volume 9, Issue 1, Pages 112–148
(Mi mbb174)
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Review Articles
Experimental and Theoretical Methods of Study of Ionic Channels
D. A. Turchenkovab, V. S. Bystrovac a Institute of Mathematical Problems of Biology RAS (IMPB RAS), Russia
b BioSim Research Group, Russia
c Experimental and Theoretical Methods of Study of Ionic Channels
Abstract:
This work realizes the review of major types and properties of ion channels, experimental and theoretical approaches and models of describing their function. Voltage-clamp and patch-clamp methods with their configuration are considered, special attention given to mathematical models of ion channels and application of molecular dynamics, Brownian dynamic simulation, Poisson–Nernst–Planck equation and modern combined approaches. Ab initio methods of quantum chemistry are presented by DFT. Application conditions for each of these methodologies with their advantages and disadvantages are represented.
Key words:
ion channels, modeling, molecular dynamics, Langevin equation, DFT.
Received 17.10.2013, Published 11.03.2014
Citation:
D. A. Turchenkov, V. S. Bystrov, “Experimental and Theoretical Methods of Study of Ionic Channels”, Mat. Biolog. Bioinform., 9:1 (2014), 112–148
Linking options:
https://www.mathnet.ru/eng/mbb174 https://www.mathnet.ru/eng/mbb/v9/i1/p112
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Statistics & downloads: |
Abstract page: | 457 | Full-text PDF : | 305 | References: | 47 |
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