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Matematicheskaya Biologiya i Bioinformatika, 2013, Volume 8, Issue 2, Pages 398–406
(Mi mbb167)
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This article is cited in 7 scientific papers (total in 7 papers)
Bioinformatics
Recognition and Stability Analysis of Structural Motifs of $\alpha$-$\alpha$-corner Type in Globular Proteins
V. R. Rudneva, A. N. Pankratovab, L. I. Kulikovaa, F. F. Dedusba, D. A. Tikhonova, A. V. Efimovc a Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Pushchino, Moskovskaya obl.
b M. V. Lomonosov Moscow State University, Faculty of Computational Mathematics and Cybernetics
c Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moskovskaya obl.
Abstract:
The problem of recognition of structural motifs of proteins is considered by the example of $\alpha$-$\alpha$-corners. We propose a hybrid approach to solving the problems of the analysis of the spatial structure of proteins based on an analytical description of the main chain of the protein globule and spectral method for detecting repetitions. We found 110 $\alpha$-$\alpha$-corners in the PDB, corresponding to a given standard. The molecular dynamics method is shown that $\alpha$-$\alpha$-corners as autonomous entities stable in the aqueous medium.
Key words:
pattern recognition, orthogonal polynomials, analytical description, super secondary structures of proteins.
Received 21.05.2013, Published 17.07.2013
Citation:
V. R. Rudnev, A. N. Pankratov, L. I. Kulikova, F. F. Dedus, D. A. Tikhonov, A. V. Efimov, “Recognition and Stability Analysis of Structural Motifs of $\alpha$-$\alpha$-corner Type in Globular Proteins”, Mat. Biolog. Bioinform., 8:2 (2013), 398–406
Linking options:
https://www.mathnet.ru/eng/mbb167 https://www.mathnet.ru/eng/mbb/v8/i2/p398
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