R. T. Sibatov, Ju. V. Saenko, V. V. Uchajkin, V. V. Saenko, E. V. Morozova, V. V. Shulezhko, E. V. Kozhemjakina, A. N. Byzykchi, G. G. Gusarov, D. A. Korobko, I. V. Jarovikova, K. V. Saltykova, I. I. Kozhemjakin, V. M. Juravlev, A. V. Juravlev, N. K. Aynullova, “Statistical Analysis of Radiation-Induced Dynamics of Cancer Cell Transcriptome Using Dna-Microarray Data”, Mat. Biolog. Bioinform., 8:2 (2013), 520

Matematicheskaya Biologiya i Bioinformatika

RUS ENG

JOURNALS PEOPLE ORGANISATIONS CONFERENCES SEMINARS VIDEO LIBRARY PACKAGE AMSBIB

JavaScript is disabled in your browser. Please switch it on to enable full functionality of the website

	General information
	Latest issue
	Archive
	Impact factor

	Search papers
	Search references

	RSS
	Latest issue
	Current issues
	Archive issues
	What is RSS

Mat. Biolog. Bioinform.:
Year:
Volume:
Issue:
Page:
	Find

Personal entry:
Login:
Password:
	Save password
	Enter
	Forgotten password?
	Register

Matematicheskaya Biologiya i Bioinformatika, 2013, Volume 8, Issue 2, Pages 520–528 (Mi mbb159)

Bioinformatics

Statistical Analysis of Radiation-Induced Dynamics of Cancer Cell Transcriptome Using Dna-Microarray Data

R. T. Sibatov^a, Ju. V. Saenko^a, V. V. Uchajkin^a, V. V. Saenko^a, E. V. Morozova^a, V. V. Shulezhko^a, E. V. Kozhemjakina^a, A. N. Byzykchi^a, G. G. Gusarov^a, D. A. Korobko^a, I. V. Jarovikova^a, K. V. Saltykova^a, I. I. Kozhemjakin^b, V. M. Juravlev^a, A. V. Juravlev^a, N. K. Aynullova^a

^a Ulyanovsk State University, Ulyanovsk, Russia Federation, Ulyanovsk, Russia
^b Lomonosov Moscow State University, Faculty of Computational Mathematics and Cybernetics MSU, Moscow, Russia

Full-text PDF (756 kB)

References:

PDF

HTML

Abstract: The DNA microarray data on radiation-induced dynamics of the transcriptome of cancer cell line HCT116 with normal and mutant gene TP53 is processed. Transcriptome is analyzed after 1, 12 and 24 hours after irradiation using the Affymetrix microarray HGU133A series. It was found that the probability characteristics of expression differences depend strongly on the intensities of the reference level, and this dependence is nonlinear in general case. We take this fact into account using the “noise envelope” algorithm in filtering, clustering and grouping. The effectiveness of the procedures can be estimated from the results of hierarchical clustering and using the method of group averages. For filtered genes, dendrograms are constructed, a preliminary comparison of gene dynamics in key signaling pathways associated with programmed cell death and DNA repair is provided.

Key words: DNA microarray, gene expression, hierarchical clustering, method of group averages.

Received 03.09.2013, Published 31.10.2013

Document Type: Article

UDC: 519.25:577.21:576.385.5:616-006.6

Language: Russian

Citation: R. T. Sibatov, Ju. V. Saenko, V. V. Uchajkin, V. V. Saenko, E. V. Morozova, V. V. Shulezhko, E. V. Kozhemjakina, A. N. Byzykchi, G. G. Gusarov, D. A. Korobko, I. V. Jarovikova, K. V. Saltykova, I. I. Kozhemjakin, V. M. Juravlev, A. V. Juravlev, N. K. Aynullova, “Statistical Analysis of Radiation-Induced Dynamics of Cancer Cell Transcriptome Using Dna-Microarray Data”, Mat. Biolog. Bioinform., 8:2 (2013), 520–528

Citation in format AMSBIB

\Bibitem{SibSaeUch13}

\by R.~T.~Sibatov, Ju.~V.~Saenko, V.~V.~Uchajkin, V.~V.~Saenko, E.~V.~Morozova, V.~V.~Shulezhko, E.~V.~Kozhemjakina, A.~N.~Byzykchi, G.~G.~Gusarov, D.~A.~Korobko, I.~V.~Jarovikova, K.~V.~Saltykova, I.~I.~Kozhemjakin, V.~M.~Juravlev, A.~V.~Juravlev, N.~K.~Aynullova

\paper Statistical Analysis of Radiation-Induced Dynamics of Cancer Cell Transcriptome Using Dna-Microarray Data

\jour Mat. Biolog. Bioinform.

\yr 2013

\vol 8

\issue 2

\pages 520--528

\mathnet{http://mi.mathnet.ru/mbb159}

Linking options:

https://www.mathnet.ru/eng/mbb159

https://www.mathnet.ru/eng/mbb/v8/i2/p520

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

Statistics & downloads:
Abstract page:	291
Full-text PDF :	90
References:	33
First page:	1

Что такое QR-код?

Registration to the website

Logotypes