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This article is cited in 6 scientific papers (total in 6 papers)
Development of process technologies, diagnostic methods, and functional materials and structures
Immobilization of photoditazine on vaterite porous particles and analysis of the system stability in model media
D. B. Trushinaabc, T. N. Borodinabc, V. V. Artemovc, T. V. Bukreevaac a National Research Centre "Kurchatov Institute", Moscow
b I. M. Sechenov First Moscow State Medical University
c FSRC "Crystallography and Photonics" RAS
Abstract:
In this paper, we present the results on immobilization of Photoditazine, the photosensitizer of the second generation, on vaterite (metastable modification of calcium carbonate) porous particles of two different sizes. The adsorption efficiency is found to be 3.0 and 3.2 wt % Photoditazine on vaterite particles with average diameters of 5 and 0.5 $\mu$m, respectively. The curves of Photoditazine desorption from vaterite particles are determined depending on the composition of the dispersion medium (water and bovine serum albumin solution). It is found that vaterite particles in water are subjected to recrystallization in accordance with the dissolution–precipitation mechanism. The presence of albumin molecules at a physiological concentration allows stabilizing metastable vaterite particles of micron and submicron size for at least 17 days.
Keywords:
Photoditazine, Vaterite Particles, Calcium Carbonate Particles, Stable Polymorphic Modification, Digital Aperture.
Received: 07.02.2018
Citation:
D. B. Trushina, T. N. Borodina, V. V. Artemov, T. V. Bukreeva, “Immobilization of photoditazine on vaterite porous particles and analysis of the system stability in model media”, Zhurnal Tekhnicheskoi Fiziki, 88:9 (2018), 1387–1393; Tech. Phys., 63:9 (2018), 1345–1351
Linking options:
https://www.mathnet.ru/eng/jtf5823 https://www.mathnet.ru/eng/jtf/v88/i9/p1387
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