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Zhurnal Tekhnicheskoi Fiziki, 2018, Volume 88, Issue 9, Pages 1359–1365
DOI: https://doi.org/10.21883/JTF.2018.09.46421.2631 (Mi jtf5818) 		 
This article is cited in 2 scientific papers (total in 2 papers)

Development of process technologies, diagnostic methods, and functional materials and structures

Investigation of toxic effect and penetration into cells of monodisperse spherical composite particles based on mesoporous silica

S. V. Shmakova, V. V. Klimenkoa, S. V. Koniakhina, D. A. Eurovb, D. A. Kurdyukovb, V. G. Golubevb

a Alferov Federal State Budgetary Institution of Higher Education and Science Saint Petersburg National Research Academic University of the Russian Academy of Sciences, St. Petersburg
b Ioffe Institute, St. Petersburg
Full-text PDF (868 kB) Citations (2)
DOI: https://doi.org/10.21883/JTF.2018.09.46421.2631
Abstract: Сomposite particles based on monodisperse spherical mesoporous silica particles (MSMSPs) are synthesized by noncovalent binding of organic active components (propidium iodide fluorescent dye and Radakchlorin photosensitizer) from aqueous solutions. Hybrid particles with a core–shell structure are synthesized, which are MSMSPs filled with Fe$_3$O$_4$ and coated with mesoporous silica, the internal surface of which is modified by Fluorescein isothiocyanate (FITC) fluorescence dye by means of chemisorption. The toxicity and penetration of the obtained particles into the cells of the HeLa and K-562 cell lines were studied. The effective photodynamic action of MSMSPs containing Radachlorin in mesopores is demonstrated, which indicates the promise of using the synthesized composite particles for medical purposes.
Funding agency Grant number
Skolkovo Community 7
Skolkovo Institute of Science and Technology 3663-MRA
S.V. Shmakov, V.V. Klimenko, and S.V. Konyakhin are grateful for the financial support of the Skolkovo Foundation (the Grant Agreement for the Russian Educational and Scientific Organization no. 7 of December 19, 2017) and the Skolkovo Institute of Science and Technology (General Agreement on Research Activities no. 3663-MRA of December 25, 2017).
Received: 29.12.2017
English version:
Technical Physics, 2018, Volume 63, Issue 9, Pages 1316–1322
DOI: https://doi.org/10.1134/S1063784218090190
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: S. V. Shmakov, V. V. Klimenko, S. V. Koniakhin, D. A. Eurov, D. A. Kurdyukov, V. G. Golubev, “Investigation of toxic effect and penetration into cells of monodisperse spherical composite particles based on mesoporous silica”, Zhurnal Tekhnicheskoi Fiziki, 88:9 (2018), 1359–1365; Tech. Phys., 63:9 (2018), 1316–1322
Citation in format AMSBIB
\Bibitem{ShmKliKon18}
\by S.~V.~Shmakov, V.~V.~Klimenko, S.~V.~Koniakhin, D.~A.~Eurov, D.~A.~Kurdyukov, V.~G.~Golubev
\paper Investigation of toxic effect and penetration into cells of monodisperse spherical composite particles based on mesoporous silica
\jour Zhurnal Tekhnicheskoi Fiziki
\yr 2018
\vol 88
\issue 9
\pages 1359--1365
\mathnet{http://mi.mathnet.ru/jtf5818}
\crossref{https://doi.org/10.21883/JTF.2018.09.46421.2631}
\elib{https://elibrary.ru/item.asp?id=36904345}
\transl
\jour Tech. Phys.
\yr 2018
\vol 63
\issue 9
\pages 1316--1322
\crossref{https://doi.org/10.1134/S1063784218090190}
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    • This publication is cited in the following 2 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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