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Zhurnal Tekhnicheskoi Fiziki, 2018, Volume 88, Issue 10, Pages 1591–1598
DOI: https://doi.org/10.21883/JTF.2018.10.46507.2372 (Mi jtf5806) 		 
Experimental instruments and technique

Double-membrane sampling system in a mass spectrometer for the study of exhaled air

V. T. Kogana, A. S. Antonova, Yu. V. Chichagova, O. S. Victorova-Leclerca, I. V. Victorova, A. V. Kozlenokb

a Ioffe Institute, St. Petersburg
b Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation, St. Petersburg
Full-text PDF (605 kB)
DOI: https://doi.org/10.21883/JTF.2018.10.46507.2372
Abstract: A double-membrane sample-introduction system is described that enables mass spectrometric determination of volatile organic compounds in air, while ensuring their detection limits are as low as a few fractions of ppb of sample composition in real time with a response delay from a few seconds to a few dozens of seconds. It includes two membrane interfaces separated by a volume, the gas pressure in which is maintained through a channel with an adjustable evacuation cross-section. The results of numerical simulation and experimental testing of the system are provided. A technique for selecting and calculating system parameters is described. The possibility of using this system for diagnosing diseases by trace amounts of biomarkers in exhaled air is discussed.
Keywords: Sample-introduction System, Membrane Interface, Response Delay, Low Penetrating Ability, Proton Transfer Reaction Mass Spectrometry (PTR-MS).
Funding agency Grant number
Foundation for Assistance to Small Innovative Enterprises within the framework of the International Program ERA.Net RUS BH 0021774
Received: 01.06.2017
Revised: 19.02.2018
English version:
Technical Physics, 2018, Volume 63, Issue 10, Pages 1543–1551
DOI: https://doi.org/10.1134/S1063784218100146
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: V. T. Kogan, A. S. Antonov, Yu. V. Chichagov, O. S. Victorova-Leclerc, I. V. Victorov, A. V. Kozlenok, “Double-membrane sampling system in a mass spectrometer for the study of exhaled air”, Zhurnal Tekhnicheskoi Fiziki, 88:10 (2018), 1591–1598; Tech. Phys., 63:10 (2018), 1543–1551
Citation in format AMSBIB
\Bibitem{KogAntChi18}
\by V.~T.~Kogan, A.~S.~Antonov, Yu.~V.~Chichagov, O.~S.~Victorova-Leclerc, I.~V.~Victorov, A.~V.~Kozlenok
\paper Double-membrane sampling system in a mass spectrometer for the study of exhaled air
\jour Zhurnal Tekhnicheskoi Fiziki
\yr 2018
\vol 88
\issue 10
\pages 1591--1598
\mathnet{http://mi.mathnet.ru/jtf5806}
\crossref{https://doi.org/10.21883/JTF.2018.10.46507.2372}
\elib{https://elibrary.ru/item.asp?id=36904528}
\transl
\jour Tech. Phys.
\yr 2018
\vol 63
\issue 10
\pages 1543--1551
\crossref{https://doi.org/10.1134/S1063784218100146}
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