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This article is cited in 1 scientific paper (total in 1 paper)
XXIII International Symposium on Nanophysics and Nanoelectronics, Nizhny Novgorod, March 11-14, 2019
Comparative study of polymer nanoparticles on the basis of caprolactone–polyvinyl alcohol mixtures with an encapsulated antitumor preparation by atomic force microscopy, X-ray diffraction, and dynamic light scattering
T. E. Sukhanovaab, M. È. Vylegzhaninaa, A. Ya. Volkova, E. R. Gasilovaa, A. A. Kutina, Moshera Samyc, Heba M. Abdallahc, Magdy M. H. Ayoubc a Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg
b S. V. Lebedev Synthetic Rubber Research Institute
c Department of Polymers and Pigments, National Research Center,
Dokki, Giza, Cairo, Egypt
Abstract:
The morphology, structure, and optical properties of composites with biodegradable polymeric particles, which are based on poly-$\varepsilon$-caprolactone–polyvinyl alcohol (stabilizer) mixtures and contain 5-Fluorouracil (an antitumor preparation), have been studied by atomic-force and optical microscopy, X-ray diffraction, and dynamic and static light scattering. Studies have shown that the morphology of synthesized composites sustains appreciable transformations depending on their stabilizer content. No crystalline reflections corresponding to 5-Fluorouracil have been revealed, thus arguing for a high dispersity of this preparation in the polymeric matrix of caprolactone. The correlations between the structural and morphological parameters, composition, stabilizer concentration and the efficiency of the encapsulation of 5-Fluorouracil by the composites have been established.
Keywords:
AFM, dynamic light scattering, X-ray analysis, polymer nanoparticles, polycaprolactone, double emulsification method, encapsulation, antitumor drugs.
Received: 28.03.2019 Revised: 28.03.2019 Accepted: 15.04.2019
Citation:
T. E. Sukhanova, M. È. Vylegzhanina, A. Ya. Volkov, E. R. Gasilova, A. A. Kutin, Moshera Samy, Heba M. Abdallah, Magdy M. H. Ayoub, “Comparative study of polymer nanoparticles on the basis of caprolactone–polyvinyl alcohol mixtures with an encapsulated antitumor preparation by atomic force microscopy, X-ray diffraction, and dynamic light scattering”, Zhurnal Tekhnicheskoi Fiziki, 89:12 (2019), 1823–1831; Tech. Phys., 64:12 (2019), 1729–1737
Linking options:
https://www.mathnet.ru/eng/jtf5425 https://www.mathnet.ru/eng/jtf/v89/i12/p1823
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