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Zhurnal Tekhnicheskoi Fiziki, 2019, Volume 89, Issue 12, Pages 1823–1831
DOI: https://doi.org/10.21883/JTF.2019.12.48477.125-19
(Mi jtf5425)
 

This article is cited in 1 scientific paper (total in 1 paper)

XXIII International Symposium on Nanophysics and Nanoelectronics, Nizhny Novgorod, March 11-14, 2019

Comparative study of polymer nanoparticles on the basis of caprolactone–polyvinyl alcohol mixtures with an encapsulated antitumor preparation by atomic force microscopy, X-ray diffraction, and dynamic light scattering

T. E. Sukhanovaab, M. È. Vylegzhaninaa, A. Ya. Volkova, E. R. Gasilovaa, A. A. Kutina, Moshera Samyc, Heba M. Abdallahc, Magdy M. H. Ayoubc

a Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg
b S. V. Lebedev Synthetic Rubber Research Institute
c Department of Polymers and Pigments, National Research Center, Dokki, Giza, Cairo, Egypt
Full-text PDF (966 kB) Citations (1)
Abstract: The morphology, structure, and optical properties of composites with biodegradable polymeric particles, which are based on poly-$\varepsilon$-caprolactone–polyvinyl alcohol (stabilizer) mixtures and contain 5-Fluorouracil (an antitumor preparation), have been studied by atomic-force and optical microscopy, X-ray diffraction, and dynamic and static light scattering. Studies have shown that the morphology of synthesized composites sustains appreciable transformations depending on their stabilizer content. No crystalline reflections corresponding to 5-Fluorouracil have been revealed, thus arguing for a high dispersity of this preparation in the polymeric matrix of caprolactone. The correlations between the structural and morphological parameters, composition, stabilizer concentration and the efficiency of the encapsulation of 5-Fluorouracil by the composites have been established.
Keywords: AFM, dynamic light scattering, X-ray analysis, polymer nanoparticles, polycaprolactone, double emulsification method, encapsulation, antitumor drugs.
Funding agency Grant number
Russian Foundation for Basic Research 17-53-61026 Åãèïåò_a
Egyptian Academy of Sciences 26599
This study was supported by the Russian Foundation for Basic Research (grant no. 17-53-61026 Egypt_a) and the Egyptian Academy of Sciences (project STDF no. 26599).
Received: 28.03.2019
Revised: 28.03.2019
Accepted: 15.04.2019
English version:
Technical Physics, 2019, Volume 64, Issue 12, Pages 1729–1737
DOI: https://doi.org/10.1134/S1063784219120235
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: T. E. Sukhanova, M. È. Vylegzhanina, A. Ya. Volkov, E. R. Gasilova, A. A. Kutin, Moshera Samy, Heba M. Abdallah, Magdy M. H. Ayoub, “Comparative study of polymer nanoparticles on the basis of caprolactone–polyvinyl alcohol mixtures with an encapsulated antitumor preparation by atomic force microscopy, X-ray diffraction, and dynamic light scattering”, Zhurnal Tekhnicheskoi Fiziki, 89:12 (2019), 1823–1831; Tech. Phys., 64:12 (2019), 1729–1737
Citation in format AMSBIB
\Bibitem{SukVylVol19}
\by T.~E.~Sukhanova, M.~\`E.~Vylegzhanina, A.~Ya.~Volkov, E.~R.~Gasilova, A.~A.~Kutin, Moshera~Samy, Heba~M.~Abdallah, Magdy~M.~H.~Ayoub
\paper Comparative study of polymer nanoparticles on the basis of caprolactone–polyvinyl alcohol mixtures with an encapsulated antitumor preparation by atomic force microscopy, X-ray diffraction, and dynamic light scattering
\jour Zhurnal Tekhnicheskoi Fiziki
\yr 2019
\vol 89
\issue 12
\pages 1823--1831
\mathnet{http://mi.mathnet.ru/jtf5425}
\crossref{https://doi.org/10.21883/JTF.2019.12.48477.125-19}
\elib{https://elibrary.ru/item.asp?id=41848213}
\transl
\jour Tech. Phys.
\yr 2019
\vol 64
\issue 12
\pages 1729--1737
\crossref{https://doi.org/10.1134/S1063784219120235}
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