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Zhurnal Tekhnicheskoi Fiziki, 2020, Volume 90, Issue 9, Pages 1601–1606
DOI: https://doi.org/10.21883/JTF.2020.09.49697.33-20 (Mi jtf5221) 		 
This article is cited in 9 scientific papers (total in 9 papers)

III International Conference Physics -- Life Sciences
Polymer materials for biomedicine

Biological and rheological properties of collagen cross-linked with glutaraldehyde

Yu. A. Nashchekinaab, O. A. Lukoninaa, D. M. Darvisha, A. V. Nashchekinb, V. Yu. Elokhovskiyc, V. E. Yudinc, N. A. Mikhailovaa

a Institute of Cytology Russian Academy of Science, St. Petersburg
b Ioffe Institute, St. Petersburg
c Peter the Great St. Petersburg Polytechnic University
Full-text PDF (867 kB) Citations (9)
DOI: https://doi.org/10.21883/JTF.2020.09.49697.33-20
Abstract: We study the effect of the concentration of glutaraldehyde that can cross-link type I collagen molecules on the collagen stability, mechanical strength, and cytotoxicity. It is shown that collagen containing 10 and 18% of glutaraldehyde exhibits the highest stability in physiological conditions. The results of rheological analysis demonstrate that, for the minimal concentration of glutaraldehyde (1%), mechanical characteristics of collagen hydrogels are improved significantly. However, the glutaraldehyde concentration higher than 10% reduces the vitality of cells by 50%.
Keywords: collagen type I, glutaraldehyde, chemical crosslinking, degradation.
Funding agency Grant number
Russian Foundation for Basic Research 20-03-00400_а
Russian Science Foundation 19-73-30003
The preparation of collagen samples and biological tests were supported by the Russian Foundation for Basic Research, project no. 20-03-00400_a. Mechanical tests were supported by the Russian Science Foundation, project no. 19-73-30003.
Received: 29.01.2020
Revised: 29.01.2020
Accepted: 17.02.2020
English version:
Technical Physics, 2020, Volume 65, Issue 9, Pages 1535–1540
DOI: https://doi.org/10.1134/S1063784220090224
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: Yu. A. Nashchekina, O. A. Lukonina, D. M. Darvish, A. V. Nashchekin, V. Yu. Elokhovskiy, V. E. Yudin, N. A. Mikhailova, “Biological and rheological properties of collagen cross-linked with glutaraldehyde”, Zhurnal Tekhnicheskoi Fiziki, 90:9 (2020), 1601–1606; Tech. Phys., 65:9 (2020), 1535–1540
Citation in format AMSBIB
\Bibitem{NasLukDar20}
\by Yu.~A.~Nashchekina, O.~A.~Lukonina, D.~M.~Darvish, A.~V.~Nashchekin, V.~Yu.~Elokhovskiy, V.~E.~Yudin, N.~A.~Mikhailova
\paper Biological and rheological properties of collagen cross-linked with glutaraldehyde
\jour Zhurnal Tekhnicheskoi Fiziki
\yr 2020
\vol 90
\issue 9
\pages 1601--1606
\mathnet{http://mi.mathnet.ru/jtf5221}
\crossref{https://doi.org/10.21883/JTF.2020.09.49697.33-20}
\elib{https://elibrary.ru/item.asp?id=44154284}
\transl
\jour Tech. Phys.
\yr 2020
\vol 65
\issue 9
\pages 1535--1540
\crossref{https://doi.org/10.1134/S1063784220090224}
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    • This publication is cited in the following 9 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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