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Zhurnal Tekhnicheskoi Fiziki, 2020, Volume 90, Issue 9, Pages 1553–1559
DOI: https://doi.org/10.21883/JTF.2020.09.49689.403-19 (Mi jtf5213) 		 
This article is cited in 2 scientific papers (total in 2 papers)

III International Conference Physics -- Life Sciences
Nanodiagnostics and probe technologies in biology and medicine

Investigation of erythrocyte transport through microchannels after the induction of oxidative stress with tert-butyl peroxide

E. A. Skverchinskayaa, O. D. Tapinovab, N. A. Filatovb, N. A. Besedinab, I. V. Minduksheva, A. S. Bukatinbc

a I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry
b Alferov Federal State Budgetary Institution of Higher Education and Science Saint Petersburg National Research Academic University of the Russian Academy of Sciences, St. Petersburg
c Institute for Analytical Instrumentation, Russian Academy of Sciences, St. Petersburg
Full-text PDF (1053 kB) Citations (2)
DOI: https://doi.org/10.21883/JTF.2020.09.49689.403-19
Abstract: To characterize the effect of oxidative stress (OS) on the ability of erythrocytes to pass through microvessels and capillaries, we studied the dynamics of the movement of human erythrocytes in vitro, in the channels of a microfluidic device, under the action of an OS inducer, tert-butyl hydroperoxide (tBH), and compared it with a cytological assessment of the transformation of cell membranes. OS induced the impairment of the control over the shape and volume of cells, the decrease in passage speed, and the occlusions of microchannels. The developed microfluidic device provided an assessment of the microreology of erythrocytes under the action of hydroperoxide. In the future, it is possible to use microfluidic analysis of erythrocytes in patients to assess the effect of xenobiotics on microrheology.
Keywords: microfluidic device, red blood cell, erythrocyte, oxidative stress, membrane transformation.
Funding agency Grant number
Russian Foundation for Basic Research 20-34-70111 Стабильность
This work was supported by the Russian Foundation for Basic Research, project no. 20-34-70111 “Stability”.
Received: 15.12.2019
Revised: 15.12.2019
Accepted: 17.02.2020
English version:
Technical Physics, 2020, Volume 65, Issue 9, Pages 1491–1496
DOI: https://doi.org/10.1134/S1063784220090236
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: E. A. Skverchinskaya, O. D. Tapinova, N. A. Filatov, N. A. Besedina, I. V. Mindukshev, A. S. Bukatin, “Investigation of erythrocyte transport through microchannels after the induction of oxidative stress with tert-butyl peroxide”, Zhurnal Tekhnicheskoi Fiziki, 90:9 (2020), 1553–1559; Tech. Phys., 65:9 (2020), 1491–1496
Citation in format AMSBIB
\Bibitem{SkvTapFil20}
\by E.~A.~Skverchinskaya, O.~D.~Tapinova, N.~A.~Filatov, N.~A.~Besedina, I.~V.~Mindukshev, A.~S.~Bukatin
\paper Investigation of erythrocyte transport through microchannels after the induction of oxidative stress with tert-butyl peroxide
\jour Zhurnal Tekhnicheskoi Fiziki
\yr 2020
\vol 90
\issue 9
\pages 1553--1559
\mathnet{http://mi.mathnet.ru/jtf5213}
\crossref{https://doi.org/10.21883/JTF.2020.09.49689.403-19}
\elib{https://elibrary.ru/item.asp?id=44154276}
\transl
\jour Tech. Phys.
\yr 2020
\vol 65
\issue 9
\pages 1491--1496
\crossref{https://doi.org/10.1134/S1063784220090236}
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    • This publication is cited in the following 2 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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