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Zhurnal Tekhnicheskoi Fiziki, 2020, Volume 90, Issue 9, Pages 1418–1427
DOI: https://doi.org/10.21883/JTF.2020.09.49671.402-19 (Mi jtf5195) 		 
This article is cited in 5 scientific papers (total in 5 papers)

III International Conference Physics -- Life Sciences
Nanomaterials in biology and medicine

Detection of cells containing internalized multidomain magnetic iron (II, III) oxide nanoparticles using the magnetic resonance imaging method

N. I. Enukashvilyab, I. E. Kotkasb, D. S. Bogolyubova, A. V. Kotovaab, I. O. Bogolyubobaa, V. V. Bagaevabc, K. A. Levchukb, I. I. Maslennikovab, D. A. Ivolginbc, A. Yu. Artamonovd, N. V. Marchenkoe, I. V. Mindukshevf

a Institute of Cytology Russian Academy of Science, St. Petersburg
b North-Western State Medical University named after I.I. Mechnikov
c Pokrovsky Stem Cell Bank, St. Petersburg, Russia
d Institute of Experimental Medicine, 197376, St. Petersburg, Russia
e Research Institute of Childhood Infections, St. Petersburg, Russia
f I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry
Full-text PDF (4118 kB) Citations (5)
DOI: https://doi.org/10.21883/JTF.2020.09.49671.402-19
Abstract: This study evaluated the feasibility of using uncoated iron (II, III) oxide nanoparticles (IONP) obtained by electric explosion of wire in air for labelling living mesenchymal stromal cells and their subsequent visualization by magnetic resonance imaging (MRI) using 1.5T clinical MRI scanners. The uptake of uncoated IONP by MSC was demonstrated for the wide range of IONP concentration in the cell culture medium. The cells did not change their proliferative activity, viability, and the set of surface markers. IONP obtained by electric explosion of wire in an atmosphere of air had a shape close to spherical. The size of nanoparticles varied from 14 to 136 nm according to dynamic lateral light scattering, laser diffraction, and transmission electron microscopy. Particles up to 136 nm comprised 75%, and particles less than 36 nm — 10% of the IONP powder. A wide range of particle sizes made it possible to select MRI parameters suitable for labelled cells detection in animal tissues both in the T2 mode and in the T1 relaxation mode.
Keywords: uncoated iron oxide nanoparticles, multidomain iron oxide nanoparticles, mesenchymal stromal cells, tracking transplanted cells in vivo, MRI, MRI, in vivo cell imaging methods, contrast agents for magnetic resonance imaging.
Funding agency Grant number
Ministry of Education and Science of the Russian Federation 056-00105-18-00
This work was carried out within the framework of research work (no. AAAA-A18-118052990081-0) of a state order to the Ministry of Health of the Russian Federation no. 056-00105-18-00.
Received: 15.12.2019
Revised: 15.12.2019
Accepted: 17.02.2020
English version:
Technical Physics, 2020, Volume 65, Issue 9, Pages 1360–1369
DOI: https://doi.org/10.1134/S1063784220090145
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: N. I. Enukashvily, I. E. Kotkas, D. S. Bogolyubov, A. V. Kotova, I. O. Bogolyuboba, V. V. Bagaeva, K. A. Levchuk, I. I. Maslennikova, D. A. Ivolgin, A. Yu. Artamonov, N. V. Marchenko, I. V. Mindukshev, “Detection of cells containing internalized multidomain magnetic iron (II, III) oxide nanoparticles using the magnetic resonance imaging method”, Zhurnal Tekhnicheskoi Fiziki, 90:9 (2020), 1418–1427; Tech. Phys., 65:9 (2020), 1360–1369
Citation in format AMSBIB
\Bibitem{EnuKotBog20}
\by N.~I.~Enukashvily, I.~E.~Kotkas, D.~S.~Bogolyubov, A.~V.~Kotova, I.~O.~Bogolyuboba, V.~V.~Bagaeva, K.~A.~Levchuk, I.~I.~Maslennikova, D.~A.~Ivolgin, A.~Yu.~Artamonov, N.~V.~Marchenko, I.~V.~Mindukshev
\paper Detection of cells containing internalized multidomain magnetic iron (II, III) oxide nanoparticles using the magnetic resonance imaging method
\jour Zhurnal Tekhnicheskoi Fiziki
\yr 2020
\vol 90
\issue 9
\pages 1418--1427
\mathnet{http://mi.mathnet.ru/jtf5195}
\crossref{https://doi.org/10.21883/JTF.2020.09.49671.402-19}
\elib{https://elibrary.ru/item.asp?id=44154258}
\transl
\jour Tech. Phys.
\yr 2020
\vol 65
\issue 9
\pages 1360--1369
\crossref{https://doi.org/10.1134/S1063784220090145}
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