Mandelstam–Brillouin light scattering in bovine serum albumin solutions with different concentrations in the vicinity of thermal denaturation

Results of Brillouin light scattering studies of phase transformations in bovine serum albumin (BSA) in the temperature range 300 – 380 K in the protein solution with concentration 50 and 5 mg/ml are presented. In the analysis of the results, the sequence of phase transformations in a concentrated BSA solution (100 mg/ml) was used as a reference. It was shown that sequence of BSA phase transformations modified with a decrease in concentration. For instance, in the vicinity of denaturation, the region with fibril-like aggregate disappears, and the properties of the gel-like high temperature phase change.