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Pis'ma v Zhurnal Èksperimental'noi i Teoreticheskoi Fiziki, 2024, Volume 119, Issue 7, Pages 552–559
DOI: https://doi.org/10.31857/S1234567824070139
(Mi jetpl7199)
 

BIOPHYSICS

Analysis of skin neoplasms' Raman spectra using the Lorentz approximation method: pilot studies

I. N. Saraevaa, E. N. Rimskayaa, A. B. Timurzievaab, A. V. Gorevoya, S. N. Shelyginaa, V. I. Popadyukc, E. V. Perevedentsevaa, S. I. Kudryashova

a Lebedev Physical Institute, Russian Academy of Sciences, Moscow, 119991 Russia
b N.A. Semashko National Research Institute of Public Health, Moscow, 105064 Russia
c Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, 117198 Russia
References:
Abstract: Confocal Raman microspectroscopy provides the ability to diagnose cancer by quantitatively analyzing spectral features and identifying underlying biochemical changes. The differentiation of malignant skin neoplasms (basal cell carcinoma, squamous cell carcinoma), benign skin neoplasms (papilloma) and healthy skin was carried out by obtaining Raman spectra in vitro with excitation wavelengths of 532 and 785 nm. We present a new method for analyzing the parameters of spectral bands, based on the calculation of the second derivative and Lorentz approximation of the spectra. Using this method on a small selection of skin tumors, we have demonstrated that processes in skin tumors can cause deformation of the proteins' secondary structure, leading to degradation and shift of the corresponding bands (972, 1655 cm$^{-1}$) to the lower frequency. Bands corresponding to lipids in skin neoplasms either broaden and increase or split into two peaks (bands 1061, 1127, 1297, 1439, 1745 cm$^{-1}$). The disruption of lipid structure, also indicated in several bands as a shift to lower wavenumbers, is possibly due to increased cell membrane fluidity in tumors. The results of the study may be useful for the development of optical biopsy methods for early diagnosis of tumors.
Funding agency Grant number
Russian Science Foundation 23-25-00249
The study was supported by the Russian Science Foundation, project no. 23-25-00249.
Received: 22.12.2023
Revised: 07.03.2024
Accepted: 07.03.2024
English version:
Journal of Experimental and Theoretical Physics Letters, 2024, Volume 119, Issue 7, Pages 556–563
DOI: https://doi.org/10.1134/S0021364023604153
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: I. N. Saraeva, E. N. Rimskaya, A. B. Timurzieva, A. V. Gorevoy, S. N. Shelygina, V. I. Popadyuk, E. V. Perevedentseva, S. I. Kudryashov, “Analysis of skin neoplasms' Raman spectra using the Lorentz approximation method: pilot studies”, Pis'ma v Zh. Èksper. Teoret. Fiz., 119:7 (2024), 552–559; JETP Letters, 119:7 (2024), 556–563
Citation in format AMSBIB
\Bibitem{SarRimTim24}
\by I.~N.~Saraeva, E.~N.~Rimskaya, A.~B.~Timurzieva, A.~V.~Gorevoy, S.~N.~Shelygina, V.~I.~Popadyuk, E.~V.~Perevedentseva, S.~I.~Kudryashov
\paper Analysis of skin neoplasms' Raman spectra using the Lorentz approximation method: pilot studies
\jour Pis'ma v Zh. \`Eksper. Teoret. Fiz.
\yr 2024
\vol 119
\issue 7
\pages 552--559
\mathnet{http://mi.mathnet.ru/jetpl7199}
\crossref{https://doi.org/10.31857/S1234567824070139}
\edn{https://elibrary.ru/BAPYKS}
\transl
\jour JETP Letters
\yr 2024
\vol 119
\issue 7
\pages 556--563
\crossref{https://doi.org/10.1134/S0021364023604153}
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