|
Pis'ma v Zhurnal Èksperimental'noi i Teoreticheskoi Fiziki, 2008, Volume 88, Issue 7, Pages 539–542
(Mi jetpl247)
|
|
|
|
This article is cited in 14 scientific papers (total in 14 papers)
MISCELLANEOUS
Switches in gene expression including microRNA and a large number of distinct mRNAs
V. P. Zhdanovab a Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia
b Department of Applied Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden
Abstract:
In eukaryotic cells, the kinetics of gene expression depend on the interplay of messenger RNAs (mRNAs), proteins, and nonprotein coding RNAs, or, more specifically, microRNAs. Some of microRNAs may target hundreds of mRNAs. To describe this case, the author proposes a kinetic model implying that the microRNA synthesis is suppressed by protein produced via translation of one of the target mRNAs. With physically reasonable model parameters, the model predicts bistability or, in other words, switches in expression of hundreds of genes.
Received: 21.07.2008
Citation:
V. P. Zhdanov, “Switches in gene expression including microRNA and a large number of distinct mRNAs”, Pis'ma v Zh. Èksper. Teoret. Fiz., 88:7 (2008), 539–542; JETP Letters, 88:7 (2008), 466–469
Linking options:
https://www.mathnet.ru/eng/jetpl247 https://www.mathnet.ru/eng/jetpl/v88/i7/p539
|
Statistics & downloads: |
Abstract page: | 213 | Full-text PDF : | 102 | References: | 56 |
|