Abstract:
Intrafollicular drug delivery is beneficial in terms of both localized therapy of relevant skin disorders and systemic transportation of bioactive molecules. Vaterite particles are capable of loading and delivering various substances to hair follicles. Possibility to control the duration of their intrafollicular degradation can improve such a particulate delivery system. Here, we propose the use of sonophoresis (1 MHz, 1 W/cm2) to accelerate the resorption of vaterite carriers inside the hair follicles of rats in vivo. The effect of sonication is demonstrated utilizing optical coherence tomography monitoring of the skin and scanning electron microscopy investigation of the plucked hairs. A nine-minute post-treatment of skin in the site of particle delivery allowed us to almost halve the time of their degradation.
This work was supported by the Russian Science Foundation (project No. 17-73-20172).
Received: 25.09.2020
Document Type:
Article
UDC:
57.043:53.09
Language: English
Citation:
Yu. I. Svenskaya, È. A. Genina, V. V. Tuchin, “Sonophoretic acceleration of degradation process for vaterite particles delivered into the hair follicles”, Izv. Sarat. Univ. Physics, 21:1 (2021), 80–85
\Bibitem{SveGenTuc21}
\by Yu.~I.~Svenskaya, \`E.~A.~Genina, V.~V.~Tuchin
\paper Sonophoretic acceleration of degradation process for vaterite particles delivered into the hair follicles
\jour Izv. Sarat. Univ. Physics
\yr 2021
\vol 21
\issue 1
\pages 80--85
\mathnet{http://mi.mathnet.ru/isuph41}
\crossref{https://doi.org/10.18500/1817-3020-2021-21-1-80-85}
Linking options:
https://www.mathnet.ru/eng/isuph41
https://www.mathnet.ru/eng/isuph/v21/i1/p80
This publication is cited in the following 4 articles:
Yulia I. Svenskaya, Roman A. Verkhovskii, Sergey M. Zaytsev, Juergen Lademann, Elina A. Genina, “Current issues in optical monitoring of drug delivery via hair follicles”, Advanced Drug Delivery Reviews, 2024, 115477
Yulia I. Svenskaya, Ekaterina V. Lengert, Yana V. Tarakanchikova, Albert R. Muslimov, Mariia S. Saveleva, Elina A. Genina, Igor L. Radchenko, Liudmila A. Stepanova, Andrey V. Vasin, Gleb B. Sukhorukov, Liudmila M. Tsybalova, “Non-invasive transcutaneous influenza immunization using vaccine-loaded vaterite particles”, J. Mater. Chem. B, 11:17 (2023), 3860
Roman A. Verkhovskii, Anastasiia A. Kozlova, Ekaterina V. Lengert, Mariia S. Saveleva, Mikhail A. Makarkin, Artem M. Mylnikov, Nikita A. Navolokin, Alla B. Bucharskaya, Georgy S. Terentyuk, Ilya A. Bosak, Natalya V. Vasilyeva, Yulia I. Svenskaya, “Cytotoxicity, Dermal Toxicity, and In Vivo Antifungal Effect of Griseofulvin-Loaded Vaterite Carriers Administered via Sonophoresis”, ACS Infect. Dis., 9:5 (2023), 1137
Mariia S. Saveleva, Ekaterina V. Lengert, Roman A. Verkhovskii, Anatolii A. Abalymov, Anton M. Pavlov, Alexey V. Ermakov, Ekaterina S. Prikhozhdenko, Sergei N. Shtykov, Yulia I. Svenskaya, “CaCO3-based carriers with prolonged release properties for antifungal drug delivery to hair follicles”, Biomater. Sci., 10:12 (2022), 3323
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