Abstract:
Magnetic nanoparticles, as controlled drug carriers, provide tremendous opportunities in treating a variety of tumors and brain diseases. In this theoretical study, we used magnetic nanoparticles, such as Superparamagnetic Iron Oxide Nanoparticles (Fe$_3$O$_4$) (SPION). Due to their biocompatibility and stability, these particles represent a unique nanoplatform with a great potential for the development of drug delivery systems. This allows them to be used in medicine for targeted drug delivery, in magnetic resonance imaging and magnetic hyperthermia. In the work, the trapping mechanisms of magnetic nanoparticles moving in a viscous fluid (blood) in a static magnetic field are numerically studied. The equations of motion for particles in the flow are governed by a combination of magnetic equations for the permanent magnet field and the Navier-Stokes equations for fluid (blood). These equations were solved numerically using the COMSOL Multiphysics$\circledR$ Modeling Software.
V.V.T. was supported by the Ministry of Science and Higher Education of the Russian Federation (project No. 075-15-2019-1885).
Received: 07.12.2019
Document Type:
Article
UDC:
532.542
Language: English
Citation:
S. Salem, V. V. Tuchin, “Trapping of magnetic nanoparticles in the blood stream under the influence of a magnetic field”, Izv. Sarat. Univ. Physics, 20:1 (2020), 72–79
\Bibitem{SalTuc20}
\by S.~Salem, V.~V.~Tuchin
\paper Trapping of magnetic nanoparticles in the blood stream under the influence of a magnetic field
\jour Izv. Sarat. Univ. Physics
\yr 2020
\vol 20
\issue 1
\pages 72--79
\mathnet{http://mi.mathnet.ru/isuph369}
\crossref{https://doi.org/10.18500/1817-3020-2020-20-1-72-79}
Linking options:
https://www.mathnet.ru/eng/isuph369
https://www.mathnet.ru/eng/isuph/v20/i1/p72
This publication is cited in the following 2 articles:
Nikhil Kumar Tamboli, Janani Srree Murallidharan, “Numerical Studies on Magnetic Driven Targeted Drug Delivery in Human Vasculature”, J Indian Inst Sci, 104:1 (2024), 111
Roman Verkhovskii, Alexey Ermakov, Oleg Grishin, Mikhail A. Makarkin, Ilya Kozhevnikov, Mikhail Makhortov, Anastasiia Kozlova, Samia Salem, Valery Tuchin, Daniil Bratashov, “The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow”, Molecules, 27:18 (2022), 6073
Citation in format AMSBIB
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