Optical study of blood rheological properties for Krushinsky–Molodkina strain rats with diabetes mellitus and acute disturbances of the cerebral circulation

Background and Objectives: The aim of the study was to assess the hemorheological parameters for rats with experimental diabetes and acute disturbances of the cerebral circulation. Materials and Methods: For modeling of the acute cerebral circulation disturbances (ACCD) the epilepsy-prone rats of Krushinsky–Molodkina strain were used. During the application of the specifically elaborated standard procedure of sound stimulation a strong sound impact leads to ACCD predominantly of the hemorrhagic type. Hemorheologic study was performed six weeks after streptozotocin administration used for modeling diabetes mellitus (DM). Results: Characteristic time of linear aggregates formation T$_1$ decreases by 21% and the rate of linear aggregates formation K$_t$ increases by 47% (p < 0.05). The erythrocyte deformability and whole blood viscosity were not changed, but the blood plasma viscosity was increased by 7% in diabetic rats compared to controls. Conclusion: Thus, DM impairs some of hemorheological parameters. However, ACCD associated with DM can lead to different changes in these parameters. Analysis of rheological parameters and the selection of adequate therapy can reduce the progression of complications and improve the quality of living with diabetes.