Abstract:
It is known that in the native state the DNA molecule always contains some amount of locally unwound regions, often called the open states of DNA. It is believed that these states play an important role in DNA-protein recognition and that the study of the open states dynamics may shed further light on the mechanisms of regulation of transcription and replication. In this paper we consider the effect of the thermostat on the movement of the open states in the artificial sequence consisting of four homogeneous regions. We construct the energetic profile of the sequence and investigate the trajectories of the movement of the open states under the action of a random force.
Keywords:
DNA open states, solitons, random force.
Received: 09.06.2015 Revised: 15.10.2015
Document Type:
Article
UDC:519.8
Language: Russian
Citation:
A. A. Grinevich, A. A. Ryasik, L. V. Yakushevich, “Motion of DNA open states influenced by random force”, Computer Research and Modeling, 7:6 (2015), 1295–1307
\Bibitem{GriRyaYak15}
\by A.~A.~Grinevich, A.~A.~Ryasik, L.~V.~Yakushevich
\paper Motion of DNA open states influenced by random force
\jour Computer Research and Modeling
\yr 2015
\vol 7
\issue 6
\pages 1295--1307
\mathnet{http://mi.mathnet.ru/crm294}
\crossref{https://doi.org/10.20537/2076-7633-2015-7-6-1295-1307}
Linking options:
https://www.mathnet.ru/eng/crm294
https://www.mathnet.ru/eng/crm/v7/i6/p1295
This publication is cited in the following 1 articles:
Alexander Basov, Mikhail Drobotenko, Alexandr Svidlov, Eugeny Gerasimenko, Vadim Malyshko, Anna Elkina, Mikhail Baryshev, Stepan Dzhimak, “Inequality in the Frequency of the Open States Occurrence Depends on Single 2H/1H Replacement in DNA”, Molecules, 25:16 (2020), 3753
Citation in format AMSBIB
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