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Computer Research and Modeling, 2017, Volume 9, Issue 6, Pages 993–1014
DOI: https://doi.org/10.20537/2076-7633-2017-9-6-993-1014
(Mi crm114)
 

This article is cited in 1 scientific paper (total in 1 paper)

ANALYSIS AND MODELING OF COMPLEX LIVING SYSTEMS

The effect of cell metabolism on biomass yield during the growth on various substrates

I. G. Minkevich

G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Nauki Ave. 5, Pushchino, Moscow Region, 142290, Russia
Full-text PDF (389 kB) Citations (1)
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Abstract: Bioenergetic regularities determining the maximal biomass yield in aerobic microbial growth on various substrates have been considered. The approach is based on the method of mass-energy balance and application of GenMetPath computer program package. An equation system describing the balances of quantities of 1) metabolite reductivity and 2) high-energy bonds formed and expended has been formulated. In order to formulate the system, the whole metabolism is subdivided into constructive and energetic partial metabolisms. The constructive metabolism is, in turn, subdivided into two parts: forward and standard. The latter subdivision is based on the choice of nodal metabolites. The forward constructive metabolism is substantially dependent on growth substrate: it converts the substrate into the standard set of nodal metabolites. The latter is, then, converted into biomass macromolecules by the standard constructive metabolism which is the same on various substrates. Variations of flows via nodal metabolites are shown to exert minor effects on the standard constructive metabolism. As a separate case, the growth on substrates requiring the participation of oxygenases and/or oxidase is considered. The bioenergetic characteristics of the standard constructive metabolism are found from a large amount of data for the growth of various organisms on glucose. The described approach can be used for prediction of biomass growth yield on substrates with known reactions of their primary metabolization. As an example, the growth of a yeast culture on ethanol has been considered. The value of maximal growth yield predicted by the method described here showed very good consistency with the value found experimentally.
Keywords: biomass growth yield, cell metabolism, constructive metabolism, energetic metabolism, nodal metabolites, mass-energy balance.
Received: 01.11.2017
Accepted: 14.11.2017
Document Type: Article
UDC: 519.8
Language: English
Citation: I. G. Minkevich, “The effect of cell metabolism on biomass yield during the growth on various substrates”, Computer Research and Modeling, 9:6 (2017), 993–1014
Citation in format AMSBIB
\Bibitem{Min17}
\by I.~G.~Minkevich
\paper The effect of cell metabolism on biomass yield during the growth on various substrates
\jour Computer Research and Modeling
\yr 2017
\vol 9
\issue 6
\pages 993--1014
\mathnet{http://mi.mathnet.ru/crm114}
\crossref{https://doi.org/10.20537/2076-7633-2017-9-6-993-1014}
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  • This publication is cited in the following 1 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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    Computer Research and Modeling
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    References:30
     
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