State system of hemoglobin and the activity of enzymes of human erythrocytes under conditions of hyperglycemia in vitro

The study of condition of the system of hemoglobin, release of peptide compounds, and proteolytic activity of human erythrocytes under conditions of hyperglycemia of varying degrees is carried out. The increase in the level of hyperglycemia is accompanied by a decrease of affinity of hemoglobin to oxygen and the growth of level of metgemoglobin, the glycosylated hemoglobin level is increased in conditions of severe hyperglycemia. The level of formation of peptides in erythrocytes and the level of output of their cells is determined by the increase in trypsin-like activity in cytosol and increased membrane permeability of red blood cells.