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Computational mathematics
Concept controlling model for arresting epidemics, including COVID-19
G. D. Kaminskiyab, Yu. I. Prostova, D. A. Semenovaa, M. Yu. Prostova, N. N. Pimenova, E. I. Veselovaa, A. S. Vinokurova, E. V. Karamovca, A. E. Panovaa, A. S. Turgievca, V. V. Chernetsovad, A. E. Lomovtseve a National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Ministry of Health of the Russian Federation, Dostoevsky St., house 4, building 2 127473, Moscow, Russia
b State Health Organization Tula Regional Center for Control and Prevention of AIDS and Infectious Diseases, Drejera embankment, house 14, 300002, Tula, Russia
c Federal State Budgetary Institution National Research Centre for Epidemiology and Microbiology named after the Honorary Academician N. F. Gamaleya of the Ministry of Health of the Russian Federation, Gamalei str., house 18, 123098, Moscow, Russia
d National Research University Moscow Power Engineering Institute, Krasnokazarmennaya str., house 17, building 3 111250, Moscow, Russia
e The Department of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing for Tula Region, Oboronnaya str., house 114, 300045, Tula, Russia
Abstract:
Concept controlling model for arresting epidemics (further on - the model) of emerging, new and re-emerging infections has been developed. Epidemic force parameters are defined: high values of contact rate of infection in acute ($ R_1 $) and chronic ($ R_2 $) forms of disease, high frequency of chronization $\gamma_2 $ with pathogen excretion, high rate of loss of natural immunity $ k_1 $, high inflow of susceptible population $\mu $. Control targets have been identified: infected persons (detection, isolation and treatment $\delta $), transmission mechanism (regime-restrictive measures, sanitary and hygienic procedures $ r $), the decrease in susceptibility (vaccination, pre- and post-exposure prophylaxis $\lambda $). Critical interdependencies between epidemic force parameters and control coefficients were studied. We obtained threshold conditions for "zero infection" asymptotic stability. In order to achieve the target result more quickly, the use of "supercritical" control levels is proposed, with the model determining the time to achieve the result. The need to affect both acute and chronic forms of infection has been proven. The model allows to solve direct and inverse problems.
Keywords:
control of communicable diseases, threshold, intervention campaign, parameters of the epidemic process, mathematical model.
Received November 29, 2022, published February 28, 2024
Citation:
G. D. Kaminskiy, Yu. I. Prostov, D. A. Semenova, M. Yu. Prostov, N. N. Pimenov, E. I. Veselova, A. S. Vinokurov, E. V. Karamov, A. E. Panova, A. S. Turgiev, V. V. Chernetsova, A. E. Lomovtsev, “Concept controlling model for arresting epidemics, including COVID-19”, Sib. Èlektron. Mat. Izv., 21:1 (2024), 125–163
Linking options:
https://www.mathnet.ru/eng/semr1673 https://www.mathnet.ru/eng/semr/v21/i1/p125
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